| CedImmum | Дата: Понедельник, 02.09.2013, 03:09 | Сообщение # 1 |
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They found that a 10mg dose of ADASUVE was found to be statistically much better at reducing symptoms of agitation compared to placebo, with symptoms of agitation dropping drastically after only 10 minutes of taking the 10mg ADUSAVE dose. According to a principal investigator in the ADASUVE clinical trials, Michael Lesem, MD, Executive Medical Director, Claghorn-Lesem Research Clinic, Houston, TX: The data we have seen from the ADASUVE Phase 3 clinical trials in patients with schizophrenia and bipolar I disorder are compelling. I believe that ADASUVE represents an important new and much needed therapeutic option in treating agitation patients who will benefit from a non-coercive therapeutic intervention that works quickly to relieve their symptoms. It should be noted that patients with asthma and chronic obstructive pulmonary disease (COPD) who took ADASUVE were found to be at a higher risk of bronchospasm. The condition causes severe problems with breathing and can eventually result in respiratory arrest or respiratory diseases. For this reason the drug's administration will be monitored by the ADASUVE Risk Evaluation and Mitigation Strategy (ADASUVE REMS). Written by Joseph Nordqvist Bipolar disorder is a serious and debilitating condition where individuals experience severe swings in mood between mania and depression. The episodes of low or elevated mood can last days or months, and the risk of suicide is high. Antidepressants are commonly prescribed to treat or prevent the depressive episodes, but they are not universally effective.
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Many patients still continue to experience periods of depression even while being treated, and many patients must try several different types of antidepressants before finding one that works for them. In addition, it may take several weeks of treatment before a patient begins to feel relief from the drug's effects. For these reasons, better treatments for depression are desperately needed. A new study in Biological Psychiatry this week confirms that scientists may have found one in a drug called ketamine. A group of researchers at the National Institute of Mental Health, led by Dr. Carlos Zarate, previously found that a single dose of ketamine produced rapid antidepressant effects in depressed patients with bipolar disorder. They have now replicated that finding in an independent group of depressed patients, also with bipolar disorder. Replication is an important component of the scientific method, as it helps ensure that the initial finding wasn't accidental and can be repeated.
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