| Kastlartesy | Дата: Четверг, 15.08.2013, 13:50 | Сообщение # 1 |
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Cholinesterase inhibitors raise the level of the neurotransmitter acetylcholine. Alzheimer's patients and people with related conditions have lower levels of acetylcholine. Raising acetylcholine levels slows down mental decline in people with Alzheimer's disease. Among the side effects associated with ChEIs, is a beneficial effect on the vagus nerve.
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The authors explained that previous studies had suggested that ChEIs might also help reduce inflammation. The scientists followed 7,073 patients with Alzheimer's disease from May 2007 to December 2010. Their details were stored on the Swedish Dementia Registry. Patients on ChEIs were found to have: a 36% lower risk of death from any cause a 48% lower risk of heart attack (myocardial infarction) a 26% lower risk of death from stroke and other cardiovascular diseases The authors wrote that they came to these figures after making adjustments for several confounding factors, including sex, age, Alzheimer's dementia diagnosis, mixed dementia diagnosis, level of care, and medical history (including medications for other conditions and illnesses). Prof Nordstrom explained: If you translate these reductions in risk into absolute figures, it means that for every 100,000 people with Alzheimer's disease, there would be 180 fewer heart attacks - 295 as opposed to 475 - and 1125 fewer deaths from all causes - 2000 versus 3125 - every year among those taking ChEIs compared to those not using them. Patients taking the highest ChEls doses had a 65% lower risk of heart attack and a 46% lower risk of death compared to those who never used the drug.
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