| CedImmum | Дата: Понедельник, 02.09.2013, 03:26 | Сообщение # 1 |
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Waldman, amplifies the sensitivity to detect cancer cells compared to histopathology. 5 percent had lymph nodes that were positive for GUCY2C. 3 percent of the patients whose lymph nodes were negative for GUCY2C developed recurrent disease. The patients were followed for a median of 24 months for disease recurrence or death. Indeed, patients who expressed GUCY2C had a shorter time to recurrence and a shorter disease-free survival. The prognostic value of the marker persisted even after a multivariate analysis that took other known prognostic factors into account.
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Waldman, 20 to 30 percent of patients diagnosed with node-negative colorectal cancer experience disease recurrence within five years. This is approximately the same rate of recurrence as that for some categories of patients diagnosed with node-positive disease. These observations suggest that there are occult metastases in the lymph nodes of node-negative patients at the time of diagnosis. GUCY2C specifically identifies these occult metastases that indicate risk for recurrent disease.
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